Curriculum Vitae - Charles Bugg

CURRICULUM VITAE

NAME: Charles Edward Bugg

BORN: June 5, 1941, Durham, North Carolina, USA

HOME ADDRESS: 303 Dexter Avenue, Birmingham, AL 35213

BUSINESS ADDRESS: BioCryst Pharmaceuticals, Inc.

2190 Parkway Lake Drive

Birmingham, Alabama 35244

TELEPHONE/FAX: Tel: 205-542-2320; Fax: 205-444-4640

FAMILY: Wife: Barbara Bradshaw Bugg of Winston-Salem, NC

Children: Jeannie Bugg Walston, born June 1, 1967

Elizabeth Bugg Holloway, born December 30,1969

Charles Edward Bugg, Jr., born January 5,1971

EDUCATION: A.B., Duke University, Durham, North Carolina, 1962

Major: Chemistry; Minor: Mathematics

Ph.D., Rice University, Houston, Texas, 1965

Physical Chemistry

POSTGRADUATE Postdoctoral Research Fellow, California Institute of Technology,

TRAINING: 1965-1966,1967-1968

RESEARCH AND/OR PROFESSIONAL EXPERIENCE:

Non-executive Chairman, BioCryst Pharmaceuticals, Inc.,

January - May 2007, prior to retiring from the company

Professor Emeritus, Department of Biochemistry and Molecular Genetics, The University

of Alabama at Birmingham, 1994-Present

Chairman and Chief Executive Officer, BioCryst Pharmaceuticals, Inc.,

Birmingham, Alabama, 1994-2006

The University of Alabama at Birmingham:

Professor Emeritus, Department of Biochemistry and Molecular Genetics, 1994-Present

Director, Center for Macromolecular Crystallography, 1985-1993

Senior Scientist, Center for AIDS Research, 1989-1993

Professor, Department of Chemistry, 1991-1993

Professor, Department of Biochemistry; Associate Director and Senior Scientist, Comprehensive Cancer Center; Senior Scientist, Research Center in Oral Biology, 1975-1993

Associate Professor, Department of Biochemistry; Scientist, Comprehensive Cancer Center;

Scientist, Research Center in Oral Biology, 1973-1974

Assistant Professor, Department of Biochemistry; Investigator, Research Center in Oral Biology, 1968-1972

Visiting Professor, Protein Crystallography, University of Oxford, England, 1974-1975, 1981

Postdoctoral work on the crystal structure of compounds related to the nucleic acids, California Institute of Technology with Dr. R.B. Corey and Dr. R.E. Marsh, 1965-1966, 1967-1968

Research Chemist with E.I. du Pont De Nemours and Company. Studies of the structures of synthetic polymers, 1966-1967

HONORS AND APPOINTMENTS:

1963-1965 National Aeronautics and Space Administration Fellowship

1965-1966 California Institute of Technology Postdoctoral Fellowship

1967-1968 California Institute of Technology Postdoctoral Fellowship

1968 National Institutes of Health Postdoctoral Fellowship

1977-1989 Editorial Board, Journal of Crystallographic and Spectroscopic Research

1984-1992 Member, U.S. National Committee for Crystallography, National

Research Council

1984-1993 NIH Molecular and Cellular Biophysics Study Section

1986 Vice-President, American Crystallographic Association

1986-1989 Chairman, Biotechnology Discipline Working Group, Universities

Space Research Association

1986-1994 Consultant, Schering-Plough Research Institute

1987 President, American Crystallographic Association

1987 Member, Committee on Industrial Applications of the

Microgravity Environment, Space Applications Board, National

Research Council

1984-1987 Co-Editor, Acta Crystallographica

1986-1993 Consultant, BioCryst Pharmaceuticals, Inc.

1987-1996 Editor-in-Chief, Acta Crystallographica; Chairman, Commission

on Journals, International Union of Crystallography

1987-1988 President, BioCryst Pharmaceuticals, Inc.

1988-1994 Member, Visiting Committee in Biology, Brookhaven National

Laboratory

1988-1993 Consultant, Eastman Kodak Company

1988-1993 Member, NASA Space Station Science and Applications Advisory

Subcommittee

1988-1989 Member, Space Applications Board, National Research Council

1989-1993 Chairman, Scientific Advisory Board, BioCryst Pharmaceuticals,

Inc.

1989-1992 Vice-Chairman, U.S. National Committee for Crystallography,

National Research Council

1989-1995 Member, Core Users Committee for the Structural Biology Center,

Advanced Photon Source, Argonne National Laboratory

1992 Chairman, Brookhaven Protein Data Bank Advisory Board

1993-Present Member, Phi Kappa Phi Honor Society

1993 Recipient, NASA Public Service Medal for significant scientific

and administrative contributions to NASA's Protein Crystal

Growth Program

1993 University of Alabama Medical Center Distinguished Faculty

Lecturer

1994-1996 Chairman, U.S. National Committee for Crystallography, National

Research Council

1994 Recipient, Milstein Award of the International Society for

Interferon and Cytokine Research

PROFESSIONAL ORGANIZATIONS:

Alabama Academy of Sciences

American Association for the Advancement of Science

American Chemical Society

American Crystallographic Association

Federation of American Societies for Experimental Biology

RESEARCH INTERESTS:

Crystallographic studies of biological systems; protein crystallography; protein crystal growth processes; applications of protein crystallography in drug design and protein engineering; molecular modeling; x-ray diffraction studies of the structures of compounds of biological interest.